Materials and Methods: This study was a randomized, controlled, open-label, comparative efficacy trial. We randomly assigned patients with migraine into cupping therapy plus serkangabin group (30 patients) and conventional treatment group (30 patients). An investigator assessed the severity of headache, frequency of attacks in a week and duration of attacks per hour in 5 visits (at the end of 2 weeks, 1, 3 and 6 months). Generalized estimating equations approach was used to analyze repeated measures data to compare outcomes in both groups. INTRODUCTION Millions of people worldwide suffer from migraine. Migraine is one of the top 20 causes of disability in the world.[,] Migraine causes morbidity and bed rest in more than half of affected people.

It causes a decrease in the quality of life, increased absenteeism and reduced productivity at work. It also increases healthcare costs.[] Migraine attack is usually managed by nonsteroidal antiinflammatory drugs, acetaminophen, 5HT 1 agonists including ergots and triptans, dopamine antagonists and sometimes opioid analgesics.[,,,,] Different medications such as β-blockers, flunarizine, valproic acid, topiramate, amitriptyline, venlafaxine, gabapentin, naproxen, butterbur root, Vitamin B 2 and magnesium are recommended for migraine prophylaxis; however, efficacy and adverse effects are still controversial.[] Many diseases especially chronic ones are neither curable nor well palliated. Ramka tituljnogo lista para. Existing treatments can impose serious adverse reactions and provision of care is fragmented and impersonal.[] Complementary alternative medicine (CAM) approach is frequently used today.

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More than 30% of Americans use CAM.[] Over the past few decades, thousands of studies have been performed via various CAM approaches. Migraine patients seek and explore both conventional and CAM approaches.[] Wet cupping is an ancient medical technique used in several contemporary societies in East Asia and the Middle East[] and it is frequently used for controlling pain.[] Types of cupping include retained cupping, flash cupping, moving cupping, wet cupping, medicinal cupping, and needling cupping.[] Wet cupping is a common method. In order to perform this procedure, a glass cup is placed on the skin and a vacuum is created inside it.

After a few minutes, a superficial incision is placed in the area to suck the blood into the cup. This is repeated several times.[] It is being used in the management of hypertension, diabetes mellitus, headaches, renal, and biliary stones and for maintaining health. Little experimental studies have been devoted to test its efficacy to treat migraine headache. Some studies stated that wet cupping have clinical benefits on pain conditions.[,,] Some studies have assessed the pain killing effect of wet cup and have found some advantages;[,,,] nevertheless, there are few studies about the effects of cupping on migraine.[] Serkangabin is a traditional drink which is frequently used for headache in Iran. In traditional Iranian medicine (TIM) it is believed that serkangabin has therapeutic effects in many diseases such as diabetes mellitus, hypertension, hyperlipidemia, ischemic heart disease, migraine and cerebrovascular diseases. According to the Iranian traditional literature, serkangabin can cause blood dilution and is easier to make compared with cupping procedure.[] Serkangabin from the words (serke, “vinegar”) and (angobin, “honey”) is a drink which is traditionally produced in Iran. We did not find any studies on the effect of serkangabin in the literature.

The mixture of these two methods (wet cupping plus serkangabin) may lead to therapeutic synergy. Therefore, this study evaluated therapeutic and prophylactic effects of cupping and serkangabin and compares it with conventional migraine therapy. Study design and participants Researchers of the CAM Research Center of Birjand University of Medical Sciences (BUMS) designed and conducted this randomized, controlled, open-label, comparative efficacy trial of cupping therapy and serkangabin versus conventional therapy in 2012. This study was approved by medical ethics committee of BUMS, and it was registered at by number of.