Routing Following the spine of the Appalachian Mountains, Interstate 81 provides a major trucking corridor and link from the Southeastern States and Tennessee Valley northward to the Northeastern Megalopolis. Interstate 81 does not enter major metropolitan areas; it instead serves an array of small to mid-size cities. The route commences from a rural directional T interchange near Dandridge, Tennessee to run northeast across agricultural areas and forest land along the west side of the Appalachian Mountains to the Tri-Cities region. A spur route, I-181, once connected I-81 with Kingsport and Johnson City. It was renumbered in 2003 as a northern extension of Interstate 26 from Asheville, North Carolina. Crossing into Virginia by the two-state city of Bristol, Interstate 81 combines with U.S. 58 through to Abingdon.

A short spur, I-381, links I-81 with the Bristol city center as the freeway bypasses the community to the north. Further east, Interstate 81 combines with Interstate 77 along a 'wrong-way' overlap, where I-77 south combines with I-81 north and vice versa due to their east-west orientation between Wytheville and Fort Chiswell.

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I-77 leads north to Charleston, West Virginia and south to Charlotte, adding truck traffic from the Carolinas to Interstate 81 as it progresses northeast to Christiansburg, Roanoke and Lexington. I-581 represents the second urban spur for Interstate 81, as it combines with U.S. 220 south through Roanoke while the parent freeway stays north by Salem. Interstate 64 combines with I-81 from Lexington northeast to Staunton as part of its east-west route between Beckley, West Virginia and Roanoke, Virginia. Additional truck traffic funnels onto I-81 south from central Virginia via I-64. Northward from their overlap, I-81 continues to Harrisonburg, Strasburg and the west end of I-66, and Winchester to exit the state through the Eastern Panhandle West Virginia. The short stretch through the Mountaineer State takes I-81 through the urban area of Martinsburg.

Firmware samsung galaxy s2 i9100gsmh. The section concludes at the Potomac River and Williamsport, Maryland. The freeway stays urban along the west side of Hagerstown between the crossroads with I-70 and Hagerstown Regional Airport (HGR). Truck traffic remains heavy as the route enters the Keystone State nearby. Angling northeast, Interstate 81 and its companion U.S.